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Treatment interruptions news

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Treatment interruptions
New data shed light on poor outcome in SMART study

In the recently discontinued SMART study, opportunistic illnesses and death occurred more often in participants with higher CD4 cell counts and lower viral loads, according

Published
17 August 2006
By
Liz Highleyman
Treatment interruptions
Staccato study suggests that some CD4-guided treatment interruptions can be safe

The results of the Staccato study, published in the August 5th edition of The Lancet, have demonstrated that CD4-guided treatment interruptions may be safe under

Published
08 August 2006
By
Christopher Gadd
Treatment interruptions
Study concludes that interleukin-2 has no benefit before HIV treatment interruptions, but increases side-effects

Injections of interleukin-2 (Proleukin) do not allow patients to remain off HIV treatment for longer, according to the final results of a randomised controlled trial.

Published
12 June 2006
By
Christopher Gadd
Drug interactions and pharmacokinetics
Variation in gene linked to risk of resistance after stopping efavirenz treatment

Patients with a common genetic mutation are at an elevated risk of developing resistance to efavirenz (Sustiva) after stopping the drug, according to a study

Published
10 April 2006
By
Christopher Gadd
Treatment interruptions
Treatment interruption arm of DART study halted

The treatment interruption arm of a major clinical trial has been terminated after it was found that patients who were randomised to cycles of HIV

Published
15 March 2006
By
Michael Carter
Resistance
CROI: Low rates of resistance seen in Staccato trial of CD4-guided treatment interruptions

Few patients enrolled in the Staccato study examining CD4 cell count-guided treatment interruptions had evidence of resistance mutations in their HIV, according to a poster

Published
27 February 2006
By
Christopher Gadd
Treatment interruptions
CROI News Feature: Experts divided over the future of treatment interruptions

Experts at the Thirteenth Conference on Retroviruses and Opportunistic Infections, held this week in Denver, were divided over the future of structured treatment interruptions during

Published
10 February 2006
By
Edwin J. Bernard
Treatment interruptions
CROI: CD4-guided treatment interruptions unsafe, SMART study concludes

The SMART trial (Strategies for Management of Antiretroviral Therapy) is a large international study designed to examine the effects of intermittent treatment in HIV-positive patients.

Published
08 February 2006
By
Christopher Gadd
Treatment interruptions
Treatment interruption study stopped after excess number of AIDS events seen in people taking treatment breaks

A major HIV treatment strategy study has been stopped early on the grounds of futility. The SMART study (Strategies for Management of Antiretroviral Therapy) was

Published
11 January 2006
By
Michael Carter
Treatment interruptions
ICAAC: Viral load between six to 18 months predicts longer-term success of HIV therapy

A detectable viral load or treatment interruption six to 18 months after starting antiretroviral therapy is a predictor of poorer survival, impaired CD4 cell gain

Published
05 January 2006
By
Michael Carter
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